Review
The challenges of overcoming antibiotic bulwark: go under extracts as potential sources of antimicrobial and resistance varying agents
T. Sibanda, and A. I. Okoh*
1
Applied and environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare. P/ come out X1314, Alice 5700, South Africa.
Accepted 3 December, 2007
The problem of antibiotic resistance, which has express the use of cheap and old antibiotics, has necessitated the need for a move search for new antimicrobial compounds. Under standing the mechanisms of resistance is heavy in the development of strategies to solving the problem. Active efflux of drugs, adjustment of tar conk out sites and enzymatic degradations are the strategies by which pathogenic bacterium acquire or develop intrinsic resistance to antibiotics.
Multi-drug resistance (MDR) pumps, capable of recognizing and expelling a variety of structurally uncorrelated compounds from the bacterial cell and conferring resistance to a wide scarper of antibiotics have since been characterized in many yard positive and gram negative pathogens like Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and, more recently, in mycobacteria. The ability of some chemical compounds (called MDR inhibitors or resistance modifying agents) to modify the resistance phenotype in bacteria by working synergistically with antibiotics in vitro has since been observed. The search for such compounds which can be combined with antibiotics in the treatment of drug resistant infections may be an election to overcoming the problem of resistance in bacteria. Crude extracts of medicinal plants stand out as veritable sources of potential resistance modifying agents and the African biosphere promises to be a potential source of...If you want to get a full essay, order it on our website: Ordercustompaper.com
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